1. Kwiatkowski, D. „Heterologe Expression und funktionelle Analyse des extrazellulären
Adhäsionsproteins Eap aus Staphylococcus aureus“ (2013), Universitätsbibliothek der Ernst-Moritz Arndt Universität Greifswald, Bachelor Thesis
The bachelor thesis was written in the laboratory of Prof. Dr. Hammerschmidt, with whom I have been working as a student assistant since the 4th semester (04/2012-09/2013)
2. Kwiatkowski, D. „Investigation of cyclin-dependent inhibitor binding kinetics“ (2015), Universitätsbibliothek der Freien Universität Berlin, Master Thesis
The master thesis was written in the laboratory of Dr. Christian M. Stegmann in the biophysical unit of the protein technologies department of Bayer Healthcare in Berlin. The work was published in two parts in the master thesis itself and as part of Ayaz, Pelin et al. (2016) – see below
3. Ayaz, Pelin, et al. “Conformational adaption may explain the slow dissociation kinetics of roniciclib (BAY 1000394), a type I CDK inhibitor with kinetic selectivity for CDK2 and CDK9.” ACS chemical biology 11.6 (2016): 1710-1719.
4. Prinz, Florian, et al. “Functional and Structural Characterization of Bub3· BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells.” Journal of Biological Chemistry 291.21 (2016): 11252-11267.
5. Zhang, Fan, et al. “Crystal Structures of Bacterial (6-4) Photolyase Mutants with Impaired DNA Repair Activity.” Photochemistry and photobiology 93.1 (2017): 304-314.
6. Schmidt, Andrea, et al. “Structural snapshot of a bacterial phytochrome in its functional intermediate state.” Nature communications 9.1 (2018): 4912.
7. Heyder, Nicolas Andreas, et al. “Signal transduction and pathogenic modifications at the melanocortin-4 receptor: a structural perspective.” Frontiers in endocrinology 10 (2019): 515.
8. Kwiatkowski, D. „Crystal structure of native light induced Meta II rhodopsin: Insights into the activation mechanism and G protein specificity“ (2020) Universitätsbibliothek der Freien Universität Berlin, Doctoral Thesis
The thesis was written in the group of Dr. Patrick Scheerer, at the institute of medical physics and biophysics at Charité Universitätsmedizin and defended at Freie Universität Berlin
9. Heyder, Nicolas A., et al. “Structure of active melancortin-4-receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.” Cell Research 31.11 (2021): 1176-1189
The work was carried out in collaboration with Nobel Prize winner Brian Kobilka. Brian had won the Nobel Prize in Chemistry in 2012, together with Robert Lefkowitz, for the discovery and mode of action of G protein coupled receptors (GPCRs). After I approached him at a conference in Berlin and asked for advice, he gave our lab various plasmids and cell lines, some of which formed the basis of this work. The methods for producing GPCRs in the lab in Berlin, were established by Nicolas after went to the laboratories of Brain in the US and in China, where he learned them.
10. Speck, David et al. “Angiotensin and endothelin receptor structures with implications for signaling regulation and pharmacological targeting.” Frontiers in Endocrinology 13 (2022): 880002
You can find an up-to-date list of all my scientific publications on Google Scholar Profil or on ORCID